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LUCA Biologics launches to address girls’ health

Sophia D. Clark by Sophia D. Clark
January 7, 2022
in Women Health
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Longtime microbial researcher Jacques Ravel, Ph.D., is placing 15 years of vaginal microbiome work into a brand new business enterprise: LUCA Biologics, so that you can increase “stay biotherapeutics” for various girls’ fitness conditions, ranging from bacterial infections like urinary tract infection and bacterial vaginosis to preterm start and infertility.

The employer’s first target will be urinary tract contamination (UTI), which’s predicted using the World Health Organization to affect as many as half of women globally but has confined treatments.

“To date, there actually isn’t any remedy for recurrent UTIs, the maximum difficult ones that leave patients in a completely challenging region,” Raja Dhir, LUCA cofounder and chairman of its board, informed FierceBiotech. Antibiotics are to be had for off-label use, Dhir stated, but if an infection is recurring, it’s either proof against the one’s tablets, or there’s something else occurring.
“A reservoir of the infectious pathogen exists within the vagina and gut; it maintains populating within the microbiota ecosystems, resulting in recurrent contamination,” he stated.

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LUCA’s pipeline, primarily based on Ravel’s work as the main scientist in the NIH’s Human Microbiome Project, is designed to prove opportunity remedies for various sicknesses and situations in women’s health. Armed with extra than 15 years’ worth of information in a bacterial strain bank and gene catalog, LUCA has created a platform that could pick out strains of microorganisms that could modulate the vaginal and urogenital microbiome. It reckons it can set up that microorganism in remedies against a range of conditions.

“We have an extraordinary possibility to make a real effect on women’s health and translate breakthroughs in microbiome technological know-how into modern therapeutics,” stated LUCA cofounder Luba Greenwood in an assertion. “We are focused on areas of high unmet medical wishes to revolutionize treatment for regularly poorly treated conditions that affect hundreds of thousands of girls the world over.”

It’s now not a huge jump to think about using a specific microorganism to manipulate and deal with bacterial infections. But how does using micro organism-primarily based remedy help someone who’s infertile or who’s vulnerable to giving delivery early?

It turns out, Ravel’s research has proven, the microorganism within the vagina plays a role in the “host response” on the subject of fertility or time of delivery, Dhir stated.

Ravel’s maximum current paper, published in March in Nature Communications, located that women with excessive levels of a positive type of microorganism have been at the lower hazard of giving beginning early, while ladies with low tiers of that microorganism had a higher risk of giving delivery early.

The Cambridge, Massachusetts, corporation stored details of its programs near the vest, announcing within the declaration that it’d pass its UTI software into “FDA trials” this fall. Dhir couldn’t provide specifics; however, each phase 1 and segment 2 research will kick off in the fall.

LUCA is the first company to launch out of Dhir’s Seed Health, a microbial sciences enterprise that identifies promising research and translates it. Dhir, the co-CEO and co-founder of Seed, declined to mention how much LUCA has inside the bank.

“There’s quite a piece going on—commonly, whilst you see biotech agencies, they’re very, very early-stage,” Greenwood stated. “What we’re excited about here is we’ve already derisked quite a bit. It’s going to be quite busy.”

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